Buspirone hydrochloride( MJ9022-1 )

Catalog No. M14129 CAS No. 33386-08-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Buspirone hydrochloride
Note

Research use only, not for human use.
Brief Description

Buspirone hydrochloride is an anxiolytic psychotropic drug, is used to treat generalized anxiety disorder (GAD).
Description

Buspirone hydrochloride is an anxiolytic psychotropic drug, is used to treat generalized anxiety disorder (GAD).(In Vitro):Buspirone hydrochloride (0-400 μg/mL; 6 hours) has cytotoxic effect in Lymphocytes. Buspirone hydrochloride (0-180 μg/mL; 0-3 hours; Lymphocytes) induces ROS formation, MMP collapse, lipid peroxidation, lysosomal damage and elevation of glutathione disulfide (GSSG).(In Vivo):Buspirone hydrochloride (1-5 mg/kg; i.p. and i.g.; for 5 days; C57BL/6N mice) reduces anxiety/depression behaviors.Buspirone hydrochloride (1-5 mg/kg; i.p. and i.g.; for 5 days; C57BL/6N mice) restores IS-shifted β-diversity in the gut microbiota.
In Vitro

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In Vivo

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Synonyms

MJ9022-1
Pathway

Endocrinology/Hormones
Target

5-HT Receptor
Recptor

5-HT| Dopamine
Research Area

Neurological Disease
Indication

——

CAS Number

33386-08-2
Formula Weight

421.96
Molecular Formula

C21H32ClN5O2
Purity

>98% (HPLC)
Solubility

Ethanol: 36 mg/mL (85.31 mM); Water: 84 mg/mL (199.07 mM); DMSO: 84 mg/mL (199.07 mM)
SMILES

Cl.O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)C1=NC=CC=N1
Chemical Name

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1.VanderMaelen CP, et al. Eur J Pharmacol, 1986, 129(1-2), 123-130.

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